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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DYNC2H1 All Species: 21.82
Human Site: Y530 Identified Species: 48
UniProt: Q8NCM8 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NCM8 NP_001073932 4307 492594 Y530 L L D Q L K L Y E Q E Q F D D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536596 4306 491933 Y530 L L D Q F K L Y E Q E Q F D D
Cat Felis silvestris
Mouse Mus musculus Q45VK7 4306 492321 Y530 L L D Q F K L Y E Q E Q F D D
Rat Rattus norvegicus Q9JJ79 4306 492200 Y530 L L D Q F K L Y E Q E Q F D D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509757 4391 500194 Y621 L L E Q F K T Y E Q E Q F D D
Chicken Gallus gallus XP_417173 4301 491979 Y528 F L E Q L K V Y E Q E Q F D D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P37276 4639 530166 V700 F H E W A R K V Q E R N F G S
Honey Bee Apis mellifera XP_395108 4023 452032 L504 P L M L T T A L E L A R A V Q
Nematode Worm Caenorhab. elegans Q19542 4171 473799 K509 T V G L I D N K N E T I N L E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P36022 4092 471329 S515 T L A S F M D S D H C P T E K
Red Bread Mold Neurospora crassa P45443 4367 495560 K717 E S D L F R K K L D T R P I F
Conservation
Percent
Protein Identity: 100 N.A. N.A. 93.5 N.A. 93.3 93 N.A. 85.8 79.7 N.A. N.A. N.A. 26.4 30.3 40.7 N.A.
Protein Similarity: 100 N.A. N.A. 96.5 N.A. 97.1 97 N.A. 91.8 89.4 N.A. N.A. N.A. 47.8 52.5 61.2 N.A.
P-Site Identity: 100 N.A. N.A. 93.3 N.A. 93.3 93.3 N.A. 80 80 N.A. N.A. N.A. 6.6 13.3 0 N.A.
P-Site Similarity: 100 N.A. N.A. 93.3 N.A. 93.3 93.3 N.A. 86.6 93.3 N.A. N.A. N.A. 33.3 20 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.8 27.6
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 48.2
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 20 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 10 0 10 0 0 0 10 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 0 0 46 0 0 10 10 0 10 10 0 0 0 55 55 % D
% Glu: 10 0 28 0 0 0 0 0 64 19 55 0 0 10 10 % E
% Phe: 19 0 0 0 55 0 0 0 0 0 0 0 64 0 10 % F
% Gly: 0 0 10 0 0 0 0 0 0 0 0 0 0 10 0 % G
% His: 0 10 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 0 0 10 0 10 0 % I
% Lys: 0 0 0 0 0 55 19 19 0 0 0 0 0 0 10 % K
% Leu: 46 73 0 28 19 0 37 10 10 10 0 0 0 10 0 % L
% Met: 0 0 10 0 0 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 10 0 10 0 0 10 10 0 0 % N
% Pro: 10 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % P
% Gln: 0 0 0 55 0 0 0 0 10 55 0 55 0 0 10 % Q
% Arg: 0 0 0 0 0 19 0 0 0 0 10 19 0 0 0 % R
% Ser: 0 10 0 10 0 0 0 10 0 0 0 0 0 0 10 % S
% Thr: 19 0 0 0 10 10 10 0 0 0 19 0 10 0 0 % T
% Val: 0 10 0 0 0 0 10 10 0 0 0 0 0 10 0 % V
% Trp: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 55 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _